Iconovo

The current study assessed the feasibility of delivering Affilogic’s anti-viral affinity proteins – Nanofitins® – against SARS-CoV-2 to the lung using Iconovo’s dry powder single-dose inhaler ICOone®. Results confirmed that Nanofitins® can be formulated as a spray-dried powder for inhaled delivery and delivered by ICOone® with maintained activity and a fine particle fraction suitable for pulmonary delivery.

“We are very pleased with the results showing that Nanofitins can be delivered successfully to the lung using ICOone®. This possibility broadens the horizon to include new and innovative treatment strategies against viral and bacterial infections with the potential to play an important role in future pandemic response,” says Johan Wäborg, CEO of Iconovo.

“Our Nanofitins® are 20 times smaller than antibodies, highly soluble and extremely stable proteins, we anticipated that formulating them for inhalation would be feasible but we did not expect Iconovo’s results with ICOone® to be so convincing from the very first test” says Olivier Kitten, CEO of Affilogic. “They really pave the way for the straightforward development of Nanofitin®-based inhaled targeted therapies”.

The results will be presented in full in a poster with the title “Novel inhaled anti-viral against SARS-CoV-2: Feasibility of developing a Nanofitin dry powder formulation for pulmonary delivery using the ICOone® single dose dry powder inhaler”, at the conference Respiratory Drug Delivery, RDD 2024 May 5-9, in Tucson, Arizona.

About RDD 2024
Respiratory Drug Delivery (RDD®) 2024 will be held at the JW Marriott Starr Pass, Tucson, Arizona, from May 5-9, 2024. This is the latest Respiratory Drug Delivery conference in a series that has run continuously since 1988 and garnered a sustained reputation for excellent content covering all aspects of drug delivery to the lungs and nose. In-depth presentations and discussion of pioneering science in tandem with exceptional networking opportunities will appeal to scientists, engineers, regulators, clinicians, solutions providers, and business professionals active in this exciting field.
 
About Nanofitins®
For any biological target, from peptides to entire cells, it is possible to generate custom Nanofitins® with a high binding affinity and controlled specificity for targeting or interacting purposes. They can thereby be designed as targeted inhibitors, mostly as a fusion of several Nanofitins® for multispecificity, or as vectors for specific transport of a third-party molecule (experience with enzymes, peptides, nanoparticles, radionuclides, cytotoxic payload, nucleic acids, CAR-T). Usual systemic routes can be traveled by Nanofitins® but their intrinsic properties make them amenable to other routes, such as pulmonary delivery.
 
About Affilogic
Affilogic is an independent private company established in Nantes, France, and specialized in the discovery, development and combinations of affinity proteins named Nanofitins® as biotherapeutics through early-stage collaborations with worldwide industry leaders in the pharmaceutical sector. For more information, please visit https://affilogic.com