Oncopeptides

The ANCHOR study is a phase 1/2 open label multicenter study evaluating the safety and efficacy of melflufen plus dexamethasone in combination with either daratumumab or bortezomib in patients with RRMM. The study started in April 2018 with 56 patients enrolled. Considering the totality of the data, melflufen 30 mg was established as the recommended dose for future combination studies in RRMM. The full article can be found here.
 
The LIGHTHOUSE study assessed melflufen plus daratumumab and dexamethasone versus daratumumab with supporting dexamethasone in patients with RRMM with disease refractory to an immunomodulatory agent and a proteasome inhibitor or who had received ≥3 prior lines of therapy including an immunomodulatory agent and a proteasome inhibitor. The study included 54 patients and met its primary endpoint despite being prematurely terminated. It concludes that melflufen plus daratumumab and dexamethasone demonstrated superior progression free survival (HR 0.18 [0.05-0.65], p=0.0032). OS data was immature (HR 0.47 [0.09-2.57], p=0.37). The safety profile was comparable to previously published melflufen studies. The full article can be found here.
 
“The ANCHOR and LIGHTHOUSE trials provide further evidence of the efficacy of melflufen in relapsed refractory multiple myeloma,” says Stefan Norin, Chief Medical Officer at Oncopeptides. “As melflufen continues its journey as an increasingly important treatment option for patients in Europe, the comprehensive data provided from these two studies provides valuable data for the understanding of combination therapy including melflufen.”
 
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