Inhalation Sciences

Palladium nanoparticle (Pd-NP) emissions from catalytic converters are emerging as a potential serious health risk. But how exactly might they behave in the lung lining of chronic and nonchronic bronchitis patients, and how can this be modelled accurately in an in vitro setting?

In this collaborative research project XposeALI^® was used to predict the toxic potential of Pd-NP using cell-line models of normal and chronic bronchitis-like mucosa cells. The study found that XposeALI^® closely mimicked in vivo lung environments and cell-particle interactions, maximizing the reliability of in vitro findings in human health toxicology risk assessments.

The publication is titled Cell line-based in vitro models of normal and chronic bronchitis-like airway mucosa to study the toxic potential of aerosolized palladium nanoparticles.

ISAB CEO Manoush Masarrat: "We were very happy to collaborate with our colleagues at KI. This project demonstrates again how XposeALI^® can generate precise data on the cellular effects of inhaled particles in the lung lining using minimal amounts of test substance and reducing the amount of animal testing needed".

Read more about XposeALI^® here.

Explore ISAB's publications here.