Genovis

AlligBAITOR represents a new category of tools within the Genovis portfolio and complements the company's established SmartEnzymes™ platform. Through high-affinity binding to the Fab region of immunoglobulins, the product captures all major antibody isotypes, including IgG, IgA, IgM, and IgE, from complex biological matrices such as human serum.

Unlike traditional antibody-binding proteins such as Protein A and Protein G, which bind only selected antibody classes, AlligBAITOR provides broad isotype coverage. In addition, the product offers a unique capability to release antigens bound to antibodies while preserving their native structure. This opens new possibilities across proteomics, bioanalysis, and diagnostics.

Interest from early access users has been strong across multiple application areas, including proteomics research, bioanalytical characterization, and diagnostic development. The broad application potential is further supported by independent academic validation. A recently published preprint from Professor Albert Heck's group at Utrecht University, one of the world's leading centers in protein mass spectrometry, demonstrates the utility of AlligBAITOR in advanced proteomics workflows and the analysis of complex biological samples.

“What has impressed me most during the early access phase is the breadth of interest we've seen across very different customer groups. Researchers in proteomics, bioanalysis, and diagnostics have all identified applications relevant to their work. This confirms that AlligBAITOR is not built around a single workflow but rather represents a platform with the potential to enable entirely new analytical strategies,” says Rolf Lood, VP R&D at Genovis.

AlligBAITOR™ is available in two product formats.

AlligBAITOR™ Lyophilized enables pan-Ig capture in solution and can simultaneously release antigens from antibody-antigen complexes under fully native conditions without the use of denaturing reagents. This capability has been demonstrated using clinically relevant antibody-antigen pairs, including trastuzumab-HER2 and adalimumab-TNFα.

AlligBAITOR™ Affinity Purification is supplied as ready-to-use microspin columns and enables rapid enrichment or depletion of immunoglobulins from serum. This improves the detection of low-abundance proteins in complex biological samples and creates new opportunities across proteomics, bioanalysis, and diagnostics.

“AlligBAITOR represents more than a product launch. Together with the proteomics tools added through the acquisition of KPL, the product strengthens our offering in advanced protein analysis and enables integrated workflows for serum and plasma proteomics. By combining immunoglobulin capture, antigen release, and high-performance enzymes in a coordinated solution, we create new opportunities for researchers to analyze complex biological samples and develop next-generation proteomics methods,” says Fredrik Olsson, CEO of Genovis.

Read more about AlligBAITOR