Cantargia

“The new results are important for our detailed understanding of the clinical stage CAN10 antibody, while also bringing light on the opportunity to affect multiple signaling pathways by targeting a single common receptor. This publication highlights the Cantargia antibodies and clearly verifies the external interest in this biological segment” said Göran Forsberg, CEO of Cantargia.

CAN10 is an IL1RAP-binding antibody in Phase I clinical development for treatment of autoimmune and inflammatory diseases. It has unique properties as it simultaneously blocks three inflammatory pathways important in several diseases. The data, now published in the journal Cell Reports, show in detail how CAN10, by binding to a specific part of IL1RAP, can efficiently block the IL-1 α/β, IL-33, and IL-36 α/β/γ signaling pathways. The publication also details biophysical and structural properties of the interaction between CAN10 and IL1RAP and shows that IL1RAP blockade has functional impact in counteracting inflammation beyond blocking only the IL-1 signaling pathway.

In addition, the now published data also details the binding and function of a second Cantargia anti-IL1RAP antibody, 3G5, which also efficiently blocks IL-1 a/b, IL-33, and IL-36 a/b/g signaling but does this via a molecular mechanism distinct from the one employed by CAN10. Thus, the new results combined with the knowledge in the Cantargia IL1RAP innovation platform add sophisticated understanding to the structure/function properties of targeting IL1RAP and thereby allows for continued strategic development of new therapeutic antibodies, tailored for specific medical needs.

The article, titled “Antibodies targeting the shared cytokine receptor IL-1 Receptor Accessory Protein (IL-1RAcP) invoke distinct mechanisms to block signaling by IL-1RAcP dependent cytokines”, was generated in a collaboration with the group of Prof. Eric J Sundberg at Emory School of Medicine, Atlanta, Dr. James Fields at Johns Hopkins School of Medicine, Baltimore, and Prof. Thoas Fioretos at Lund University. The article is available via the following link: https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00427-3.