Bonesupport

The SOLARIO* trial involves 500 adult patients with orthopedic infections who are followed for one year. The study's objective is to assess whether patients treated surgically with local antibiotic-eluting bone defect fillers, such as CERAMENT® G and CERAMENT® V, achieve similar outcomes when receiving either a short-term course of systemic antibiotics (up to seven days) or the conventional long-term regimen (at least four weeks of systemic antibiotics).

If the shorter systemic antibiotic regimen, with local antibiotics, proves to be non-inferior, it could offer significant advantages, including reduced antibiotic treatment duration and costs, fewer side effects, improved patient compliance, enhanced antimicrobial stewardship, with a decreased risk of antibiotic resistance. The results are expected to be published during next year.

*Dudareva M, Kumin M, Vach W, Kaier K, Ferguson J, McNally M, Scarborough M. Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO): a randomized controlled open-label non-inferiority trial of duration of systemic antibiotics in adults with orthopaedic infection treated operatively with local antibiotic therapy. Trials 2019; 20: 693.