Bonesupport

The prospective clinical study conducted at Charité – Universitätsmedizin Berlin, involved twenty patients with confirmed PJI of the hip. The procedure included implant removal, debridement (removal of infected tissue), and defect augmentation using CERAMENT G, followed by cementless revision arthroplasty in a single stage procedure. None of the patients experienced a re-infection during the 24-month follow-up period. Significant improvements were observed in patient-reported outcomes eg. the Harris Hip Score, EQ-5D-5L and Pain Visual Analogue Scale (VAS).

"Periprosthetic joint infections are among the most challenging complications in orthopedic surgery. Despite our best efforts, reinfection and defect reconstruction remain a significant challenge. However, innovative solutions like the gentamicin-eluting bone graft substitute CERAMENT G offer a promising new tool for effectively treating patients with single-stage revision in hip surgery,” said Dr. Med. Sebastian Meller.

According to the German Arthroplasty Registry (Endoprothesenregister Deutschland) the risk of reinfection is 30% within two years following hip revision surgery. The current standard of care remains a two-stage procedure, where the infection is treated in a primary surgery and the new prosthesis is implanted in a second surgery up to eight weeks later.

The study (CeraHip) is expected to be published during the autumn.