AlzeCure Pharma

“The fourth quarter of 2023 continued to be positive and eventful for AlzeCure Pharma. During the period, we presented new preclinical data which show that our clinical drug candidate NeuroRestore ACD856 potentially has neuroprotective and disease-modifying effects in Alzheimer’s and other neurodegenerative diseases. We also received new patents for ACD856 and published new data for NeuroRestore and Alzstatin validating the target mechanisms and stimulating interest in the two Alzheimer’s programs. In addition, we presented phase II clinical results for ACD440 for the treatment of peripheral neuropathic pain. It is both motivating and gratifying that we are keeping up the pace as we continue to deliver new data that strengthen our position. Furthermore, we have now also selected a drug candidate in our TrkA-NAM project, ACD137.”

Martin Jönsson, CEO

Financial information for October – December, 2023
Figures in parentheses refer to the corresponding period of the previous year.

• Net sales during the period totaled SEK 0 thousand (0).
• Earnings for the period totaled SEK -9,756 thousand (-10,948).
• Earnings per share, basic, totaled SEK -0.16 (-0.22).
• Cash flow from operating activities totaled SEK -8,361 thousand (-51,194).
• Total assets at the end of the period amounted to SEK 32,001 thousand (70,836).
• Cash and cash equivalents at the end of the period totaled SEK 29,100 thousand (25,577).

Financial information for January – December, 2023
Figures in parentheses refer to the corresponding period of the previous year.

• Net sales during the period totaled SEK 0 thousand (0).
• Earnings for the period totaled SEK -37,167 thousand (-56,239).
• Earnings per share, basic, totaled SEK -0.60 (-1.18).
• Cash flow from operating activities totaled SEK 3,057 thousand (-99,911).
• Total assets at the end of the period amounted to SEK 32,001 thousand (70,836).
• Cash and cash equivalents at the end of the period totaled SEK 29,100 thousand (25,577).

Significant events during the period October – December, 2023

• The company reports in early October that Japan has granted a patent for NeuroRestore ACD856.
• In October, the company publishes a new article about the target mechanism behind Alzstatin, which is being developed for the treatment of Alzheimer’s disease.

Significant events during the period January – September, 2023

• In January, the company selects a candidate drug (CD) and initiates the preclinical development phase with the company’s preventive and disease-modifying drug candidate Alzstatin ACD680.
• In January, the last patient is included in the Phase II clinical trial with the leading non-opioid drug candidate in the Painless platform, ACD440, which is being developed to treat peripheral neuropathic pain.
• The company announces on March 13 that the last patient has completed treatment in the above clinical trial with ACD440.
• In April, the company has an abstract on non-opioid ACD440 for neuropathic pain accepted at the EFIC 2023 Conference.
• On May 17, the company holds its Annual General Meeting and Dr Janet Hoogstraate is elected to serve as a new member of the Board of Directors.
• The company announces on May 22 that a European patent has been granted for the NeuroRestore ACD856 Alzheimer’s project.
• On May 24 the company announces positive proof-of-mechanism (PoM) data from the Phase IIa clinical trial in neuropathic pain with the non-opioid ACD440.
• On July 3, the company publishes a new scientific article presenting preclinical results demonstrating the antidepressant effects of NeuroRestore ACD856.
• On July 11, the company publishes new disease-modifying data regarding NeuroRestore ACD856 for the treatment of Alzheimer’s and cognitive disorders.
• On August 9, the company publishes favorable clinical results from the Phase I clinical trial with NeuroRestore ACD856 for the treatment of Alzheimer’s.
• On September 20, the company presents positive Phase II clinical data on ACD440 for neuropathic pain at the 2023 European Pain Federation (EFIC) conference.

Significant events after the end of the period

• On January 29, the company selects a drug candidate and enter the next phase of development with TrkA-NAM ACD137 for the treatment of osteoarthritis pain and other severe pain conditions.

The full report is attached as PDF and is available on the company’s website: www.alzecurepharma.com/en/section/investors/financial-reports/